BDBM50075099 CHEMBL580421::TCMDC-124224

SMILES CC1(C)C(=O)N=C2C1=C(O)C(=O)c1ccccc21

InChI Key InChIKey=BAQXWJQSUXZVIP-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50075099   

TargetN-lysine methyltransferase KMT5A(Human)
The Center For Combinatorial Chemistry and Drug Discovery of Jilin University

Curated by ChEMBL
LigandPNGBDBM50075099(TCMDC-124224 | CHEMBL580421)
Affinity DataIC50: 700nMAssay Description:Inhibition of N-terminal His6-tagged human SETD8 (191 to 352 residues) expressed in Escherichia coli Rosseta-2(DE3) cells using histone peptide subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
The Center For Combinatorial Chemistry and Drug Discovery of Jilin University

Curated by ChEMBL
LigandPNGBDBM50075099(TCMDC-124224 | CHEMBL580421)
Affinity DataIC50: 700nMAssay Description:Inhibition of SETD8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
The Center For Combinatorial Chemistry and Drug Discovery of Jilin University

Curated by ChEMBL
LigandPNGBDBM50075099(TCMDC-124224 | CHEMBL580421)
Affinity DataIC50: 700nMAssay Description:Inhibition of N-terminal His6-tagged human SETD8 (191 to 352) assessed as incorporation of [3H]-methyl group from [3H-Me]-SAM to biotinylated H4K20 p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
The Center For Combinatorial Chemistry and Drug Discovery of Jilin University

Curated by ChEMBL
LigandPNGBDBM50075099(TCMDC-124224 | CHEMBL580421)
Affinity DataEC50: <5.00E+3nMAssay Description:Inhibition of SETD8 in HEK293T cells assessed as reduction in H4K20me level after 2 to 3 days by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed