BDBM50075534 5-(3,5-Di-tert-butyl-4-methoxy-phenyl)-[1,3,4]thiadiazole-2-thiol::CHEMBL16828

SMILES COc1c(cc(cc1C(C)(C)C)-c1nnc(S)s1)C(C)(C)C

InChI Key InChIKey=OOQUQJACOYHCKO-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50075534   

TargetProstaglandin G/H synthase 2(Mouse)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50075534(5-(3,5-Di-tert-butyl-4-methoxy-phenyl)-[1,3,4]thia...)
Affinity DataIC50: 300nMAssay Description:IC50 value against Prostaglandin G/H synthase 2 of murine J774A.1 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50075534(5-(3,5-Di-tert-butyl-4-methoxy-phenyl)-[1,3,4]thia...)
Affinity DataIC50: 920nMAssay Description:Tested for inhibition of 5-LO by measuring the reduction of leukotriene B4 (LTB4) in intact basophilic rat leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50075534(5-(3,5-Di-tert-butyl-4-methoxy-phenyl)-[1,3,4]thia...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of recombinant human prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50075534(5-(3,5-Di-tert-butyl-4-methoxy-phenyl)-[1,3,4]thia...)
Affinity DataIC50: 2.00E+4nMAssay Description:IC50 value against Prostaglandin G/H synthase 1 of human platelet rich plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50075534(5-(3,5-Di-tert-butyl-4-methoxy-phenyl)-[1,3,4]thia...)
Affinity DataIC50: 2.00E+4nMAssay Description:IC50 value against ovine Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed