BDBM50075719 3-[3-Allyl-4-(3-hydroxy-1-aza-bicyclo[2.2.2]oct-3-ylethynyl)-phenyl]-propionic acid ethyl ester::CHEMBL24362

SMILES CCOC(=O)CCc1ccc(C#CC2(O)CN3CCC2CC3)c(CC=C)c1

InChI Key

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50075719   

TargetSqualene synthase(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50075719(3-[3-Allyl-4-(3-hydroxy-1-aza-bicyclo[2.2.2]oct-3-...)
Affinity DataKi:  6nMAssay Description:Tested for its inhibitory activity against rat microsomal quinuclidine squalene synthase (SQS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetSqualene synthase(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50075719(3-[3-Allyl-4-(3-hydroxy-1-aza-bicyclo[2.2.2]oct-3-...)
Affinity DataIC50: 6nMAssay Description:Compound was measured for the inhibition of rat microsomal squalene synthase enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50075719(3-[3-Allyl-4-(3-hydroxy-1-aza-bicyclo[2.2.2]oct-3-...)
Affinity DataKi:  43nMAssay Description:Tested for its inhibitory activity against human microsomal quinuclidine squalene synthase (SQS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetLanosterol synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075719(3-[3-Allyl-4-(3-hydroxy-1-aza-bicyclo[2.2.2]oct-3-...)
Affinity DataIC50: 100nMAssay Description:Inhibition of compound was measured on rat microsomal Oxidosqualene-lanosterol cyclaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed