BDBM50076273 (2R,3R)-2,3-Bis-[(E)-3-(3,4-dihydroxy-phenyl)-acryloyloxy]-succinic acid::1-chicoricacid::CHEMBL282731::Cichoric acid (CHA)::HIV-1 Integrase Inhibitor::L-chicoric acid::cichoric acid
SMILES OC(=O)[C@H](OC(=O)\C=C\c1ccc(O)c(O)c1)[C@@H](OC(=O)\C=C\c1ccc(O)c(O)c1)C(O)=O
InChI Key InChIKey=YDDGKXBLOXEEMN-IABMMNSOSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 13 hits for monomerid = 50076273
TargetTyrosine-protein phosphatase YopH(Yersinia enterocolitica)
Universidade Federal De Santa Catarina
Curated by ChEMBL
Universidade Federal De Santa Catarina
Curated by ChEMBL
Affinity DataKi: 1.25E+4nMAssay Description:Non-competitive mixed inhibition of Yersinia enterocolitica YopH assessed as inhibition constant for enzyme-substrate complexMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase YopH(Yersinia enterocolitica)
Universidade Federal De Santa Catarina
Curated by ChEMBL
Universidade Federal De Santa Catarina
Curated by ChEMBL
Affinity DataKi: 6.83E+4nMAssay Description:Non-competitive mixed inhibition of Yersinia enterocolitica YopH assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 1.40E+6nMAssay Description:Steady-state kinetic parameters were measured for PTP1B using p-nitrophenyl phosphate (pNPP, 0.5−40 mM) as the substrate in NMR buffer. The rat...More data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda
Curated by ChEMBL
National Cancer Institute-Bethesda
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Compound was evaluated for the inhibitory concentration against HIV-1 integrase by radiolabeled oligonucleotide-based assay 3''-processingMore data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda
Curated by ChEMBL
National Cancer Institute-Bethesda
Curated by ChEMBL
Affinity DataIC50: 2.49E+4nMAssay Description:Inhibitory activity against HIV-1 integraseMore data for this Ligand-Target Pair
Affinity DataIC50: 34nMAssay Description:Inhibition of HIV-1 subtype C integrase in presence of biotinylated DNA by colorimetric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of HIV1 integrase using U5A/U5B double-stranded DNA as substrate by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 1.55E+4nMAssay Description:Inhibition of HIV1 recombinant integrase expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase YopH(Yersinia enterocolitica)
Universidade Federal De Santa Catarina
Curated by ChEMBL
Universidade Federal De Santa Catarina
Curated by ChEMBL
Affinity DataIC50: 3.79E+5nMAssay Description:Inhibition of recombinant Yersinia enterocolitica YopH assessed as reduction in conversion of pNPP to nitrophenol and inorganic phosphate using pNPP ...More data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda
Curated by ChEMBL
National Cancer Institute-Bethesda
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Inhibition of HIV-1 integrase by radiolabeled oligonucleotide-based assay integrationMore data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda
Curated by ChEMBL
National Cancer Institute-Bethesda
Curated by ChEMBL
Affinity DataIC50: 1.37E+4nMAssay Description:Inhibitory activity against HIV-1 integraseMore data for this Ligand-Target Pair
Affinity DataKd: 1.60E+6nMAssay Description:NMR chemical shift perturbations of PTP1B resonances due to binding of CHA and CGA were monitored by acquiring a series of 1H−15N TROSY spectra...More data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda
Curated by ChEMBL
National Cancer Institute-Bethesda
Curated by ChEMBL
Affinity DataKd: 3.00E+3nMAssay Description:Kd value against HIV-1 integraseMore data for this Ligand-Target Pair