BDBM50078688 3-(3,4-Difluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-5H-furan-2-one::3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)furan-2(5H)-one::CHEMBL18264
SMILES CS(=O)(=O)c1ccc(cc1)C1=C(C(=O)OC1)c1ccc(F)c(F)c1
InChI Key InChIKey=INRQTVDUZFESAO-UHFFFAOYSA-N
Data 12 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 50078688
TargetProstaglandin G/H synthase 1(Human)
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 1.53E+4nMAssay Description:Inhibitory potency against Prostaglandin G/H synthase 1 in human whole blood assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Human)
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibitory concentration against prostaglandin G/H synthase 1 in human whole bloodMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 480nMAssay Description:Inhibitory potency against cyclooxygenase-2 in human whole blood assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 900nMAssay Description:Inhibitory concentration against prostaglandin G/H synthase 2 in human whole bloodMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Human)
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:In vitro inhibitory activity against human whole cells Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of COX2 in guinea pig blood assessed as reduction of LPS-induced PGE2 accumulation at 10 to 10000 nM preincubated with LPS followed by com...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 900nMAssay Description:In vitro inhibitory activity against human whole blood Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Human)
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 1.30E+4nMAssay Description:In vitro inhibitory activity against human whole blood Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 230nMAssay Description:Inhibitory potency against Prostaglandin G/H synthase 1 in human whole blood assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Human)
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory activity against recombinant human Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of COX2 in rabbit whole blood assessed as reduction of LPS-induced PGE2 accumulation at 10 to 10000 nM preincubated with LPS followed by c...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:In vitro inhibitory activity against human whole cells (CHO) Prostaglandin G/H synthase 2More data for this Ligand-Target Pair