BDBM50080572 CHEMBL333667::N-(2-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethylamino}-ethyl)-2-phenyl-acetamide

SMILES Fc1ccc(cc1)C(OCCNCCNC(=O)Cc1ccccc1)c1ccc(F)cc1

InChI Key InChIKey=ZOVQSSMFGDAFDJ-UHFFFAOYSA-N

Data  3 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50080572   

TargetSodium-dependent dopamine transporter(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50080572(N-(2-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethylamino...)
Affinity DataKi:  54nMAssay Description:Inhibition of [125I]RTI-55 binding at Dopamine transporter (DAT) expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50080572(N-(2-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethylamino...)
Affinity DataIC50: 80nMAssay Description:Inhibition of [3H]DA uptake in HEK cells expressing dopamine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50080572(N-(2-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethylamino...)
Affinity DataIC50: 399nMAssay Description:Inhibition of [3H]- NE uptake in HEK cells expressing norepinephrine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50080572(N-(2-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethylamino...)
Affinity DataKi:  556nMAssay Description:Inhibition of [125I]RTI-55 binding to serotonin transporter (SERT) expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50080572(N-(2-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethylamino...)
Affinity DataKi:  604nMAssay Description:Inhibition of [125I]RTI-55 binding to norepinephrine transporter (NET) expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50080572(N-(2-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethylamino...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of [3H]- 5-HT uptake in HEK cells expressing serotonin transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed