BDBM50082367 4-(4-Methanesulfonyl-phenyl)-5,5-dimethyl-3-(pyrimidin-2-yloxy)-5H-furan-2-one::CHEMBL326254

SMILES CC1(C)OC(=O)C(Oc2ncccn2)=C1c1ccc(cc1)S(C)(=O)=O

InChI Key InChIKey=CFLVAXAAGJCMLB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50082367   

TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082367(4-(4-Methanesulfonyl-phenyl)-5,5-dimethyl-3-(pyrim...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of COX-1 in U-937 (human lymphoma) cell microsomes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082367(4-(4-Methanesulfonyl-phenyl)-5,5-dimethyl-3-(pyrim...)
Affinity DataIC50:  860nMAssay Description:Inhibition of PGE-2 production in CHO cells expressing human COX-2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082367(4-(4-Methanesulfonyl-phenyl)-5,5-dimethyl-3-(pyrim...)
Affinity DataIC50:  620nMAssay Description:Inhibition of PGE-2 production in CHO cells expressing human COX-2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed