BDBM50083811 3-({1-[3-(1H-Imidazol-2-ylamino)-propyl]-1H-indazole-5-carbonyl}-amino)-2-(2,4,6-trimethyl-benzenesulfonylamino)-propionic acid::CHEMBL346934

SMILES Cc1cc(C)c(c(C)c1)S(=O)(=O)N[C@@H](CNC(=O)c1ccc2n(CCCNc3ncc[nH]3)ncc2c1)C(O)=O

InChI Key InChIKey=UQSXTDKNKMCKEM-NRFANRHFSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50083811   

TargetIntegrin alpha-V/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50083811(3-({1-[3-(1H-Imidazol-2-ylamino)-propyl]-1H-indazo...)
Affinity DataIC50:  2.30nMAssay Description:Inhbitory activity against beta3-transfected 293 cells using alpha-V beta-3 antagonism assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V(Mouse)
University of Bradford

Curated by ChEMBL
LigandPNGBDBM50083811(3-({1-[3-(1H-Imidazol-2-ylamino)-propyl]-1H-indazo...)
Affinity DataIC50:  2.30nMAssay Description:Antagonist activity at mouse endothelial alphavbeta3 integrin receptor by cell adhesion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin beta-3(Mouse)
University of Bradford

Curated by ChEMBL
LigandPNGBDBM50083811(3-({1-[3-(1H-Imidazol-2-ylamino)-propyl]-1H-indazo...)
Affinity DataIC50:  21nMAssay Description:Antagonist activity at mouse endothelial alpha2bbeta3 integrin receptor by cell adhesion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50083811(3-({1-[3-(1H-Imidazol-2-ylamino)-propyl]-1H-indazo...)
Affinity DataIC50:  21nMAssay Description:Inhibition of aggregation of human gel-purified platelets (GPIIbIIIa GPP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed