BDBM50084336 CHEMBL69380::[1-(2-Benzhydryloxy-ethyl)-piperidin-3-ylmethyl]-[2-(4-fluoro-phenyl)-ethyl]-methyl-amine

SMILES CN(CCc1ccc(F)cc1)CC1CCCN(CCOC(c2ccccc2)c2ccccc2)C1

InChI Key InChIKey=XVRWPBKYLFMIHN-UHFFFAOYSA-N

Data  3 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50084336   

TargetSodium-dependent dopamine transporter(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50084336([1-(2-Benzhydryloxy-ethyl)-piperidin-3-ylmethyl]-[...)
Affinity DataKi:  90nMAssay Description:Inhibition of [125I]RTI-55 binding to dopamine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50084336([1-(2-Benzhydryloxy-ethyl)-piperidin-3-ylmethyl]-[...)
Affinity DataKi:  110nMAssay Description:Binding affinity at the norepinephrine transporter was measured using [125I]RTI-55 as a radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50084336([1-(2-Benzhydryloxy-ethyl)-piperidin-3-ylmethyl]-[...)
Affinity DataIC50: 350nMAssay Description:Inhibition of [3H]NE reuptake by human norepinephrine transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50084336([1-(2-Benzhydryloxy-ethyl)-piperidin-3-ylmethyl]-[...)
Affinity DataKi:  530nMAssay Description:Binding affinity for serotonin transporter using [125I]RTI-55More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50084336([1-(2-Benzhydryloxy-ethyl)-piperidin-3-ylmethyl]-[...)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of [3H]dopamine reuptake in HEK293 cells expressing human dopamine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50084336([1-(2-Benzhydryloxy-ethyl)-piperidin-3-ylmethyl]-[...)
Affinity DataIC50: 2.13E+3nMAssay Description:Inhibition of [3H]5-HT reuptake in HEK293 cells expressing human serotonin transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2012
Entry Details Article
PubMed