BDBM50087067 CHEMBL31326::N-[4-(3-Bromo-phenylamino)-7-(3-diethylamino-propylsulfanyl)-quinazolin-6-yl]-acrylamide

SMILES CCN(CC)CCCSc1cc2ncnc(Nc3cccc(Br)c3)c2cc1NC(=O)C=C

InChI Key InChIKey=DHTCKGXFZBUXRM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50087067   

TargetEpidermal growth factor receptor(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50087067(N-[4-(3-Bromo-phenylamino)-7-(3-diethylamino-propy...)
Affinity DataIC50: 0.780nMAssay Description:Inhibition of phosphorylation of a polyglutamic acid/tyrosine random copolymer by EGFR enzyme prepared from human A431 carcinoma cell vesicles by imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50087067(N-[4-(3-Bromo-phenylamino)-7-(3-diethylamino-propy...)
Affinity DataIC50: 196nMAssay Description:Inhibition of EGF-stimulated autophosphorylation of EGFR enzyme in A431 cells detected by immunoblottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed