BDBM50087070 CHEMBL32844::N-{4-(3-Bromo-phenylamino)-7-[3-(4-methyl-piperazin-1-yl)-propoxy]-quinazolin-6-yl}-acrylamide

SMILES CN1CCN(CCCOc2cc3ncnc(Nc4cccc(Br)c4)c3cc2NC(=O)C=C)CC1

InChI Key InChIKey=IWAYNBDAXAGXQK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50087070   

TargetEpidermal growth factor receptor(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50087070(N-{4-(3-Bromo-phenylamino)-7-[3-(4-methyl-piperazi...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of phosphorylation of a polyglutamic acid/tyrosine random copolymer by EGFR enzyme prepared from human A431 carcinoma cell vesicles by imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50087070(N-{4-(3-Bromo-phenylamino)-7-[3-(4-methyl-piperazi...)
Affinity DataIC50: 3nMAssay Description:Inhibition of EGF-stimulated autophosphorylation of EGFR enzyme in A431 cells detected by immunoblottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed