BDBM50087072 CHEMBL31630::N-[4-(3-Chloro-4-fluoro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-pyrido[3,2-d]pyrimidin-6-yl]-N-methyl-acrylamide

SMILES CN(C(=O)C=C)c1nc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OCCCN1CCOCC1

InChI Key InChIKey=FHHOEGKZVIYWLM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50087072   

TargetEpidermal growth factor receptor(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50087072(N-[4-(3-Chloro-4-fluoro-phenylamino)-7-(3-morpholi...)
Affinity DataIC50: 20nMAssay Description:Inhibition of phosphorylation of a polyglutamic acid/tyrosine random copolymer by EGFR enzyme prepared from human A431 carcinoma cell vesicles by imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50087072(N-[4-(3-Chloro-4-fluoro-phenylamino)-7-(3-morpholi...)
Affinity DataIC50: 88nMAssay Description:Inhibition of EGF-stimulated autophosphorylation of EGFR enzyme in A431 cells detected by immunoblottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50087072(N-[4-(3-Chloro-4-fluoro-phenylamino)-7-(3-morpholi...)
Affinity DataIC50: 200nMAssay Description:Inhibition of autophosphorylation of ERBB2 receptor kinase in MDA-MB 453 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed