BDBM50088336 9-(3,4-Dichloro-benzylidene)-7-aza-tricyclo[4.3.1.0*3,7*]decane-2-carboxylic acid methyl ester::CHEMBL304656

SMILES COC(=O)[C@H]1C2CC[C@@H]3C[C@@H]1\C(CN23)=C\c1ccc(Cl)c(Cl)c1

InChI Key

Data  12 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50088336   

TargetSodium-dependent serotonin transporter(Human)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50088336(9-(3,4-Dichloro-benzylidene)-7-aza-tricyclo[4.3.1....)
Affinity DataKi:  0.560nMAssay Description:Compound was evaluated for binding affinity using [125I]RTI-55 as a radioligand in HEK-hSERT cells expressing human serotonin transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50088336(9-(3,4-Dichloro-benzylidene)-7-aza-tricyclo[4.3.1....)
Affinity DataKi:  20nMAssay Description:Inhibition of reuptake of [3H]5-HT at serotonin transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50088336(9-(3,4-Dichloro-benzylidene)-7-aza-tricyclo[4.3.1....)
Affinity DataKi:  20nMAssay Description:Inhibition of reuptake of [3H]5-HT at serotonin transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50088336(9-(3,4-Dichloro-benzylidene)-7-aza-tricyclo[4.3.1....)
Affinity DataKi:  30nMAssay Description:Compound was evaluated for inhibition of [3H]5-HT uptake in HEK-hSERT cells expressing Human serotonin transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50088336(9-(3,4-Dichloro-benzylidene)-7-aza-tricyclo[4.3.1....)
Affinity DataKi:  640nMAssay Description:Compound was evaluated for inhibition of [3H]NE uptake in HEK-hNET cells expressing Human norepinephrine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50088336(9-(3,4-Dichloro-benzylidene)-7-aza-tricyclo[4.3.1....)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of reuptake of [3H]-NE at Norepinephrine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50088336(9-(3,4-Dichloro-benzylidene)-7-aza-tricyclo[4.3.1....)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of reuptake of [3H]-NE at Norepinephrine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50088336(9-(3,4-Dichloro-benzylidene)-7-aza-tricyclo[4.3.1....)
Affinity DataKi:  1.92E+3nMAssay Description:Inhibition of reuptake of [3H]DA at Dopamine transporter (DAT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50088336(9-(3,4-Dichloro-benzylidene)-7-aza-tricyclo[4.3.1....)
Affinity DataKi:  1.92E+3nMAssay Description:Inhibition of reuptake of [3H]DA at Dopamine transporter (DAT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50088336(9-(3,4-Dichloro-benzylidene)-7-aza-tricyclo[4.3.1....)
Affinity DataKi:  3.32E+3nMAssay Description:Compound was evaluated for binding affinity to dopamine transporter using [125I]RTI-55 as a radioligand in HEK cells expressing human transporters.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50088336(9-(3,4-Dichloro-benzylidene)-7-aza-tricyclo[4.3.1....)
Affinity DataKi:  3.77E+3nMAssay Description:Compound was evaluated for binding affinity using [125I]RTI-55 as a radioligand in HEK-hNET cells expressing human norepinephrine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50088336(9-(3,4-Dichloro-benzylidene)-7-aza-tricyclo[4.3.1....)
Affinity DataKi: >1.00E+4nMAssay Description:Compound was evaluated for inhibition of [3H]DA uptake in HEK-hDAT cells expressing Human dopamine TransporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed