BDBM50092229 7-tert-Butyl-5-(4-chloro-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine::CHEMBL306012

SMILES CC(C)(C)n1cc(-c2ccc(Cl)cc2)c2c(N)ncnc12

InChI Key InChIKey=CYTZASCNUGMIJP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50092229   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092229(7-tert-Butyl-5-(4-chloro-phenyl)-7H-pyrrolo[2,3-d]...)
Affinity DataIC50:  2.68E+3nMAssay Description:Inhibition of Vascular endothelial growth factor receptor 2 at 5 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092229(7-tert-Butyl-5-(4-chloro-phenyl)-7H-pyrrolo[2,3-d]...)
Affinity DataIC50:  150nMAssay Description:Inhibition of src at 5 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092229(7-tert-Butyl-5-(4-chloro-phenyl)-7H-pyrrolo[2,3-d]...)
Affinity DataIC50:  220nMAssay Description:Inhibition of p56 Lck tyrosine kinase at 5 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092229(7-tert-Butyl-5-(4-chloro-phenyl)-7H-pyrrolo[2,3-d]...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of tie-2 at 5 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed