BDBM50092327 CHEMBL3581652::US9675697, RX-45

SMILES CCc1noc(CC)c1-c1cc2[nH]c3ccnc(Cl)c3c2cc1OC

InChI Key InChIKey=CKQYQLKQWQCCMP-UHFFFAOYSA-N

Data  5 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50092327   

TargetBromodomain-containing protein 3 [326-398](Human)
University of Michigan

US Patent
LigandPNGBDBM50092327(US9675697, RX-45 | CHEMBL3581652)
Affinity DataKi:  3.44E+3nM ΔG°:  -7.45kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
Go to US Patent

TargetBromodomain-containing protein 2 [364-436](Human)
University of Michigan

US Patent
LigandPNGBDBM50092327(US9675697, RX-45 | CHEMBL3581652)
Affinity DataKi:  8.32E+3nM ΔG°:  -6.93kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50092327(US9675697, RX-45 | CHEMBL3581652)
Affinity DataKi:  8.32E+3nMAssay Description:Displacement of FAM-labeled ZBA248 from BRD4 BD2 (333 to 460 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells after 30 mins by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50092327(US9675697, RX-45 | CHEMBL3581652)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of FAM-labeled ZBA248 from BRD4 BD1 (44 to 168 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells after 30 mins by fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [75-147](Human)
University of Michigan

US Patent
LigandPNGBDBM50092327(US9675697, RX-45 | CHEMBL3581652)
Affinity DataKi: >1.00E+4nM ΔG°: >-6.82kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50092327(US9675697, RX-45 | CHEMBL3581652)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of FAM-labeled ZBA248 from BRD4 BD1 (44 to 168 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells after 30 mins by fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50092327(US9675697, RX-45 | CHEMBL3581652)
Affinity DataIC50: 7.40E+4nMAssay Description:Displacement of FAM-labeled ZBA248 from BRD4 BD2 (333 to 460 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells after 30 mins by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2016
Entry Details Article
PubMed