BDBM50092711 CHEMBL339457::N,N-Diethyl-4-[(3-fluoro-phenyl)-piperidin-4-ylidene-methyl]-benzamide

SMILES CCN(CC)C(=O)c1ccc(C(=C2CCNCC2)c2cccc(F)c2)cc1

InChI Key InChIKey=OCXDOWNNRXFVKZ-UHFFFAOYSA-N

Data  7 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50092711   

TargetDelta-type opioid receptor(Human)
AstraZeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092711BDBM50092711(N,N-Diethyl-4-[(3-fluoro-phenyl)-piperidin-4-ylide...)
Affinity DataIC50: 0.440nMAssay Description:Displacement of radiolabeled iodinated deltorphin 2 from delta opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
AstraZeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092711BDBM50092711(N,N-Diethyl-4-[(3-fluoro-phenyl)-piperidin-4-ylide...)
Affinity DataIC50: 0.740nMAssay Description:Binding affinity on cloned opioid receptor delta 1 in human HEK293S cells using [125I]-[D-Ala2]-deltorphin II as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
AstraZeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092711BDBM50092711(N,N-Diethyl-4-[(3-fluoro-phenyl)-piperidin-4-ylide...)
Affinity DataEC50:  4.60nMAssay Description:Effective concentration as delta agonist potency using [35S]GTP-gamma-S binding assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50092711BDBM50092711(N,N-Diethyl-4-[(3-fluoro-phenyl)-piperidin-4-ylide...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
AstraZeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092711BDBM50092711(N,N-Diethyl-4-[(3-fluoro-phenyl)-piperidin-4-ylide...)
Affinity DataIC50: 3.50E+3nMAssay Description:Displacement of radiolabeled FK33-824 from mu opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
AstraZeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092711BDBM50092711(N,N-Diethyl-4-[(3-fluoro-phenyl)-piperidin-4-ylide...)
Affinity DataIC50: 3.57E+3nMAssay Description:Binding affinity on cloned opioid receptor mu 1 in human HEK293S cells using [125I]FK33824 as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
AstraZeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092711BDBM50092711(N,N-Diethyl-4-[(3-fluoro-phenyl)-piperidin-4-ylide...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity on cloned opioid receptor kappa 1 in human HEK293S cells using [125I]-D-Pro10-dynorphin A[1-11] as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBile salt export pump(Human)
AstraZeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092711BDBM50092711(N,N-Diethyl-4-[(3-fluoro-phenyl)-piperidin-4-ylide...)
Affinity DataIC50: 8.61E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2019
Entry Details Article
PubMed