BDBM50092943 1-(4-Acetyl-piperazin-1-yl)-3-[3-chloro-4-(2,4-dichloro-phenylsulfanyl)-phenyl]-propenone::CHEMBL101416

SMILES CC(=O)N1CCN(CC1)C(=O)\C=C\c1ccc(Sc2ccc(Cl)cc2Cl)c(Cl)c1

InChI Key InChIKey=JAUMKMDGCWUQCV-XVNBXDOJSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50092943   

LigandPNGBDBM50092943(1-(4-Acetyl-piperazin-1-yl)-3-[3-chloro-4-(2,4-dic...)
Affinity DataIC50:  140nMAssay Description:Ability to block the interaction between integrin LFA-1 and its adhesion partner ICAM-1 in a time-resolved fluorescent LFA-1/ICAM-1 biochemical inter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetIntercellular adhesion molecule 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50092943(1-(4-Acetyl-piperazin-1-yl)-3-[3-chloro-4-(2,4-dic...)
Affinity DataIC50:  240nMAssay Description:Evaluated for its ability to block the adherence of JY-8 cells to immobilized ICAM-1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50092943(1-(4-Acetyl-piperazin-1-yl)-3-[3-chloro-4-(2,4-dic...)
Affinity DataIC50:  130nMAssay Description:Inhibition of LFA-1 mediated JY-8 cell adhesion to ICAM-1, range (100-600)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetIntegrin alpha-L(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50092943(1-(4-Acetyl-piperazin-1-yl)-3-[3-chloro-4-(2,4-dic...)
Affinity DataIC50:  140nMAssay Description:Inhibition of intercellular adhesion molecule-1 (ICAM-1) binding to recombinant LFA-1, range(100-200)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50092943(1-(4-Acetyl-piperazin-1-yl)-3-[3-chloro-4-(2,4-dic...)
Affinity DataIC50:  140nMAssay Description:Ability to antagonise the Leukocyte function-associated Antigen-1/ Intracellular Adhesion molecule-1 interaction (LFA-1/ICAM-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed