BDBM50092998 CHEMBL72786::Derivative of Natrindole

SMILES CCCCC(=N)NCc1ccc2[nH]c3c(c2c1)C[C@@]1(O)C2Cc4ccc(O)c5c4C1(CCN2CC1CC1)C3O5

InChI Key InChIKey=LHABVQRHEYQPMS-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50092998   

TargetKappa-type opioid receptor(Guinea pig)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092998BDBM50092998(Derivative of Natrindole | CHEMBL72786)
Affinity DataKi:  0.0610nMAssay Description:Compound was evaluated for its binding affinity to CHO cells expressing cloned human Opioid receptor kappa 1 by displacing [3H]U-69593More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092998BDBM50092998(Derivative of Natrindole | CHEMBL72786)
Affinity DataKi:  3.5nMAssay Description:Compound was evaluated for its binding affinity against Opioid receptor mu 1 of guinea pig brain membrane by displacing [3H]DAMGOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092998BDBM50092998(Derivative of Natrindole | CHEMBL72786)
Affinity DataKi:  5.5nMAssay Description:Compound was evaluated for functional opioid activity by stimulation of [35S]GTP-gamma-S, in cloned human Opioid receptor delta 1 transfected into CH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed