BDBM50096018 6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)HEXANOIC ACID::6-(3-Methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)-hexanoic acid::CHEMBL135287

SMILES Cc1c(O)c2ccccc2c(O)c1C=CCCCC(O)=O

InChI Key InChIKey=PUMYZRHSPSBIKX-UHFFFAOYSA-N

Data  2 KI  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50096018   

TargetGlutathione reductase(Plasmodium falciparum (isolate 3D7))
Université

Curated by ChEMBL
LigandPNGBDBM50096018(6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)H...)
Affinity DataKi:  3.60E+3nMAssay Description:Inhibitory concentration against Plasmodium falciparum glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlutathione reductase, mitochondrial(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50096018(6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)H...)
Affinity DataKi:  3.70E+3nMAssay Description:Inhibitory concentration against human glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlutathione reductase(Plasmodium falciparum (isolate 3D7))
Université

Curated by ChEMBL
LigandPNGBDBM50096018(6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)H...)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibitory concentration against Plasmodium falciparum glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlutathione reductase, mitochondrial(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50096018(6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)H...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibitory concentration against human glutathione reductase in the the presence of 200 uM exogenous NADPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTrypanothione reductase(Trypanosoma cruzi)
Umr 8525 Cnrs - Université

Curated by ChEMBL
LigandPNGBDBM50096018(6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)H...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlutathione reductase, mitochondrial(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50096018(6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)H...)
Affinity DataIC50:  2.60E+3nMAssay Description:In vitro inhibition of human Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlutathione reductase, mitochondrial(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50096018(6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)H...)
Affinity DataIC50:  500nMAssay Description:In vitro inhibition of Plasmodium falciparum Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlutathione reductase, mitochondrial(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50096018(6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)H...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibitory concentration against human glutathione reductase in the absence of glucose-6-phosphate dehydrogenase (G6PDH)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlutathione reductase, mitochondrial(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50096018(6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)H...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibitory concentration against human glutathione reductase in the the presence of 200 uM exogenous NADPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlutathione reductase, mitochondrial(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50096018(6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)H...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibitory concentration against human glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed