BDBM50097969 3-(4-Amino-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester::CHEMBL353823

SMILES CC(C)(C)OC(=O)N1CCC(C1)n1cc(-c2ccccc2)c2c(N)ncnc12

InChI Key InChIKey=CXIHOIXBRUXAHK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50097969   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Novartis Pharma Research

Curated by ChEMBL
LigandPNGBDBM50097969(3-(4-Amino-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl)-...)
Affinity DataIC50: 180nMAssay Description:Inhibition of p60 c-Src tyrosine kinase enzyme activity in liquid-phase tyrosine phosphorylation assay at 830 ng/mLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
Novartis Pharma Research

Curated by ChEMBL
LigandPNGBDBM50097969(3-(4-Amino-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl)-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Concentration required for inhibition of c-Src mediated phosphorylation of Fak in IC8.1 fibroblast cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Novartis Pharma Research

Curated by ChEMBL
LigandPNGBDBM50097969(3-(4-Amino-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl)-...)
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of epidermal growth factor receptor (EGF-R)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed