BDBM50098947 3-(3-Fluoro-phenyl)-3,4-dihydro-isoquinolin-1-ylamine::CHEMBL440270

SMILES NC1=NC(Cc2ccccc12)c1cccc(F)c1

InChI Key InChIKey=KLWZVSPGLUAFIN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50098947   

TargetNitric oxide synthase, endothelial(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50098947(3-(3-Fluoro-phenyl)-3,4-dihydro-isoquinolin-1-ylam...)
Affinity DataIC50: 9.00E+3nMAssay Description:Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by endothelial NOS (e NOS) from HUVEC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Rat)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50098947(3-(3-Fluoro-phenyl)-3,4-dihydro-isoquinolin-1-ylam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by neuronal NOS (n NOS) from rat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed