BDBM50098960 5-Ethynyl-2-methyl-4,5-dihydro-thieno[2,3-c]pyridin-7-ylamine::CHEMBL8304

SMILES Cc1cc2CC(N=C(N)c2s1)C#C

InChI Key InChIKey=YZFZKTWAMLXSPG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50098960   

TargetNitric oxide synthase, brain(Rat)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50098960(5-Ethynyl-2-methyl-4,5-dihydro-thieno[2,3-c]pyridi...)
Affinity DataIC50: 910nMAssay Description:Ability to inhibit the conversion of [3H]-L-Arg to [3H]L-citrulline catalyzed by n-NOS from rat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50098960(5-Ethynyl-2-methyl-4,5-dihydro-thieno[2,3-c]pyridi...)
Affinity DataIC50: 3.50E+3nMAssay Description:Ability to inhibit the conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by i-NOS from human DLD-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50098960(5-Ethynyl-2-methyl-4,5-dihydro-thieno[2,3-c]pyridi...)
Affinity DataIC50: 1.00E+4nMAssay Description:Ability to inhibit the conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by e-NOS from HUVEC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed