BDBM50099902 4-[4-(3-Hydroxy-phenyl)-thiazol-2-yl]-5-methylsulfanyl-thiophene-2-carboxamidine::CHEMBL28849

SMILES CSc1sc(cc1-c1nc(cs1)-c1cccc(O)c1)C(N)=N

InChI Key InChIKey=KLVFDMVKNCAXRG-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50099902   

TargetUrokinase-type plasminogen activator(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099902(4-[4-(3-Hydroxy-phenyl)-thiazol-2-yl]-5-methylsulf...)
Affinity DataKi:  86nMAssay Description:Inhibitory activity against serine protease urokinase-type plasminogen activator (microPa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099902(4-[4-(3-Hydroxy-phenyl)-thiazol-2-yl]-5-methylsulf...)
Affinity DataKi:  930nMAssay Description:Inhibitory activity against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099902(4-[4-(3-Hydroxy-phenyl)-thiazol-2-yl]-5-methylsulf...)
Affinity DataKi:  1.70E+3nMAssay Description:Inhibitory activity against tissue plasminogen activatorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099902(4-[4-(3-Hydroxy-phenyl)-thiazol-2-yl]-5-methylsulf...)
Affinity DataKi: >2.50E+4nMAssay Description:Inhibitory activity against Thrombin (no observable inhibition at this screening concentration)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymotrypsin-C(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099902(4-[4-(3-Hydroxy-phenyl)-thiazol-2-yl]-5-methylsulf...)
Affinity DataKi: >3.10E+4nMAssay Description:Inhibitory activity against Serine protease chymotrypsin (no observable inhibition at this screening concentration)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099902(4-[4-(3-Hydroxy-phenyl)-thiazol-2-yl]-5-methylsulf...)
Affinity DataKi:  3.21E+4nMAssay Description:Inhibitory activity against plasminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed