BDBM50102284 10-Benzyl-3-phenyl-10H-benzo[4,5]imidazo[2,1-c][1,2,4]triazin-4-one::CHEMBL326752

SMILES O=c1c(nnc2n(Cc3ccccc3)c3ccccc3n12)-c1ccccc1

InChI Key InChIKey=UPGOQMMSMGYTMO-UHFFFAOYSA-N

Data  6 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50102284   

TargetAdenosine receptor A2b(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50102284(10-Benzyl-3-phenyl-10H-benzo[4,5]imidazo[2,1-c][1,...)
Affinity DataIC50: 54.3nMAssay Description:Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetAdenosine receptor A1(Bovine)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50102284(10-Benzyl-3-phenyl-10H-benzo[4,5]imidazo[2,1-c][1,...)
Affinity DataKi:  184nMAssay Description:Intrinsic activity towards Adenosine A1 receptor as displacement of [3H]DPCPX from bovine cortical membranes with 1 mM GTPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Bovine)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50102284(10-Benzyl-3-phenyl-10H-benzo[4,5]imidazo[2,1-c][1,...)
Affinity DataKi:  240nMAssay Description:Intrinsic activity towards Adenosine A1 receptor as displacement of [3H]DPCPX from bovine cortical membranes without GTPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Bovine)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50102284(10-Benzyl-3-phenyl-10H-benzo[4,5]imidazo[2,1-c][1,...)
Affinity DataKi:  274nMAssay Description:Displacement of [3H]CHA from adenosine A1 receptors was determined in bovine cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50102284(10-Benzyl-3-phenyl-10H-benzo[4,5]imidazo[2,1-c][1,...)
Affinity DataKi:  299nMAssay Description:Displacement of [3H]DPCPX from human A1 adenosine receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50102284(10-Benzyl-3-phenyl-10H-benzo[4,5]imidazo[2,1-c][1,...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]NECA from human A2A adenosine receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50102284(10-Benzyl-3-phenyl-10H-benzo[4,5]imidazo[2,1-c][1,...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]AB-MECA from human A3 adenosine receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed