BDBM50105102 4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazine-1-carboxylic acid [2-(4-ethoxy-phenyl)-ethyl]-amide::CHEMBL113956

SMILES CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1

InChI Key InChIKey=NFBNIRNKYJTDIE-UHFFFAOYSA-N

Data  20 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50105102   

TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50105102(4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazine-1-c...)
Affinity DataIC50:  993nMAssay Description:Inhibition of alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(1A) dopamine receptor(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50105102(4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazine-1-c...)
Affinity DataIC50:  967nMAssay Description:Inhibition of human dopamine receptor D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDelta-type opioid receptor(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50105102(4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazine-1-c...)
Affinity DataIC50:  8.57E+3nMAssay Description:Inhibition of ligand binding to human delta opioid receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H2 receptor(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50105102(4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazine-1-c...)
Affinity DataIC50:  757nMAssay Description:Inhibition of histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSubstance-P receptor(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50105102(4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazine-1-c...)
Affinity DataIC50:  839nMAssay Description:Binding affinity against tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSubstance-K receptor(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50105102(4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazine-1-c...)
Affinity DataIC50:  5.18E+3nMAssay Description:Binding affinity against tachykinin receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A3(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50105102(4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazine-1-c...)
Affinity DataIC50:  2.46E+3nMAssay Description:Inhibition of human adenosine A3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 7(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50105102(4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazine-1-c...)
Affinity DataIC50:  2.04E+3nMAssay Description:Inhibition of human 5-hydroxytryptamine 7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50105102(4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazine-1-c...)
Affinity DataIC50:  4.12E+3nMAssay Description:Binding affinity against opioid receptor kappa 1 by using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 2A(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50105102(4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazine-1-c...)
Affinity DataIC50:  231nMAssay Description:Inhibition of human 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(3) dopamine receptor(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50105102(4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazine-1-c...)
Affinity DataIC50:  341nMAssay Description:Inhibition of human dopamine receptor D3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent dopamine transporter(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50105102(4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazine-1-c...)
Affinity DataIC50:  994nMAssay Description:Binding affinity against dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSigma non-opioid intracellular receptor 1(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50105102(4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazine-1-c...)
Affinity DataIC50:  482nMAssay Description:Inhibition of sigma receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(1B) dopamine receptor(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50105102(4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazine-1-c...)
Affinity DataIC50:  1.45E+3nMAssay Description:Inhibition of human dopamine receptor D5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(2) dopamine receptor(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50105102(4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazine-1-c...)
Affinity DataIC50:  2.89E+3nMAssay Description:Inhibition of human dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 6(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50105102(4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazine-1-c...)
Affinity DataIC50:  800nMAssay Description:Inhibition of human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50105102(4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazine-1-c...)
Affinity DataIC50:  1.82E+3nMAssay Description:Inhibition of histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50105102(4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazine-1-c...)
Affinity DataIC50:  4.55E+3nMAssay Description:Binding affinity against mu opiate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 2C(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50105102(4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazine-1-c...)
Affinity DataIC50:  1.42E+3nMAssay Description:Inhibition of human 5-hydroxytryptamine 2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50105102(4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazine-1-c...)
Affinity DataIC50:  860nMAssay Description:Binding affinity against L-type calcium channel verapamil siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed