BDBM50109222 8-Cyano-1-(2-fluoro-benzyl)-7-(4-isobutoxy-phenyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid 1-ethyl-propyl ester::CHEMBL443027

SMILES CCC(CC)OC(=O)c1cn(Cc2ccccc2F)c2c(C#N)c(c(CN(C)CCc3ccccn3)n2c1=O)-c1ccc(OCC(C)C)cc1

InChI Key InChIKey=YDMAKFAZWUHFEF-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50109222   

TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50109222(8-Cyano-1-(2-fluoro-benzyl)-7-(4-isobutoxy-phenyl)...)
Affinity DataKi:  25nMAssay Description:Binding affinity against human GnRH receptor expressed in HEK293 cells using des-Gly10[125I]Tyr5, D-Leu, NMeLeu, Pro-NEt GnRH as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50109222(8-Cyano-1-(2-fluoro-benzyl)-7-(4-isobutoxy-phenyl)...)
Affinity DataKi:  7.30E+3nMAssay Description:Binding affinity against gonadotropin-releasing hormone receptor of ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed