BDBM50109943 3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-pyrazolo[1,5-a]pyridine-7-carbonitrile::CHEMBL160626

SMILES Clc1ccc(cc1)N1CCN(Cc2cnn3c(cccc23)C#N)CC1

InChI Key InChIKey=STIRDGXSGQTCAJ-UHFFFAOYSA-N

Data  9 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50109943   

TargetD(4) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50109943(3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-pyraz...)
Affinity DataKi:  1.5nMAssay Description:In vitro binding affinity at human cloned dopamine receptor D4 stably expressed in CHO cells by [3H]spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(4) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50109943(3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-pyraz...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]-spiperone from human D4 receptor expressed in CHO cells assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed

Target5-hydroxytryptamine receptor 1A(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50109943(3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-pyraz...)
Affinity DataKi:  2.20E+3nMAssay Description:Compound was tested in vitro for its ability to compete with [3H]8-OH-DPAT at 5-hydroxytryptamine 1A receptor in porcine brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(1A) dopamine receptor(Bovine)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50109943(3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-pyraz...)
Affinity DataKi:  2.50E+3nMAssay Description:In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50109943(3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-pyraz...)
Affinity DataKi:  2.60E+4nMAssay Description:In vitro binding affinity at human cloned dopamine receptor D3 stably expressed in CHO cells by [3H]spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(3) dopamine receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50109943(3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-pyraz...)
Affinity DataKi:  2.60E+4nMAssay Description:Binding affinity to human D3R assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed

TargetD(2) dopamine receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50109943(3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-pyraz...)
Affinity DataKi:  4.40E+4nMAssay Description:Binding affinity to human D2R assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed

TargetD(2) dopamine receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50109943(3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-pyraz...)
Affinity DataKi:  4.40E+4nMAssay Description:Binding affinity of compound was tested in vitro for its ability to compete with [3H]spiperone radioligand at cloned human Dopamine receptor D2L stab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(2) dopamine receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50109943(3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-pyraz...)
Affinity DataKi:  4.50E+4nMAssay Description:In vitro binding affinity at human cloned dopamine receptor D2 (short) stably expressed in CHO cells by [3H]spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(4) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50109943(3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-pyraz...)
Affinity DataEC50:  1.5nMAssay Description:Tested for the effective concentration against human D4.2 receptor in CHO 10001 cells established in mitogenesis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed