BDBM50112229 5-(4-Methoxy-phenyl)-1-methyl-2-oxo-6-phenyl-1,2-dihydro-pyridine-3-carboxylic acid methyl ester::CHEMBL301195

SMILES COC(=O)c1cc(-c2ccc(OC)cc2)c(-c2ccccc2)n(C)c1=O

InChI Key InChIKey=VDDATJOZLCYXHB-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50112229   

TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112229(5-(4-Methoxy-phenyl)-1-methyl-2-oxo-6-phenyl-1,2-d...)
Affinity DataKi:  210nMAssay Description:Binding affinity by displacement of [3H]Ro-151788 from recombinant human gamma-aminobutyric-acid A receptor alpha3,beta3,gamma2 stably expressed in L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112229(5-(4-Methoxy-phenyl)-1-methyl-2-oxo-6-phenyl-1,2-d...)
Affinity DataKi:  340nMAssay Description:Displacement of [3H]Ro-151788 from human Gamma-aminobutyric acid A receptor alpha-2-beta-3-gamma-2 stably expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112229(5-(4-Methoxy-phenyl)-1-methyl-2-oxo-6-phenyl-1,2-d...)
Affinity DataKi:  393nMAssay Description:Inhibition of [3H]Ro-151788 binding to human GABA A receptor (alpha-5-beta-3-gamma-2) stably expressed in L(tk-) cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112229(5-(4-Methoxy-phenyl)-1-methyl-2-oxo-6-phenyl-1,2-d...)
Affinity DataKi:  625nMAssay Description:Displacement of [3H]Ro-151788 from human GABA-A receptor alpha-1-beta-3-gamma-2 subunits expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed