BDBM50112237 1'-Methyl-5'-(4-methyl-thiazol-2-yl)-1'H-[4,2';3',4'']terpyridin-6'-one::CHEMBL59427

SMILES Cc1csc(n1)-c1cc(-c2ccncc2)c(-c2ccncc2)n(C)c1=O

InChI Key InChIKey=QAMANTJYKWSLNP-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50112237   

TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112237(1'-Methyl-5'-(4-methyl-thiazol-2-yl)-1'H-[4,2';3',...)
Affinity DataKi:  6.70nMAssay Description:Binding affinity by displacement of [3H]-Ro-15-1788 from recombinant human gamma-aminobutyric-acid A receptor alpha3,beta3,gamma2 stably expressed in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112237(1'-Methyl-5'-(4-methyl-thiazol-2-yl)-1'H-[4,2';3',...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]-Ro-15-1788 from human GABA-A receptor alpha2-beta3-gamma2 subunits expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112237(1'-Methyl-5'-(4-methyl-thiazol-2-yl)-1'H-[4,2';3',...)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]-Ro-15-1788 from human GABA-A receptor alpha1-beta3-gamma2 subunits expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112237(1'-Methyl-5'-(4-methyl-thiazol-2-yl)-1'H-[4,2';3',...)
Affinity DataKi:  270nMAssay Description:Displacement of [3H]-Ro-15-1788 from human GABA-A receptor alpha5-beta3-gamma2 subunits expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed