BDBM50112238 5-(5-Cyclopropyl-[1,2,4]oxadiazol-3-yl)-3-(4-methoxy-phenyl)-1-methyl-1H-[2,4']bipyridinyl-6-one::CHEMBL55570

SMILES COc1ccc(cc1)-c1cc(-c2noc(n2)C2CC2)c(=O)n(C)c1-c1ccncc1

InChI Key InChIKey=MHVBIDYSCZQVSY-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50112238   

TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112238(5-(5-Cyclopropyl-[1,2,4]oxadiazol-3-yl)-3-(4-metho...)
Affinity DataKi:  60nMAssay Description:Binding affinity by displacement of [3H]Ro-151788 from recombinant human gamma-aminobutyric-acid A receptor alpha3,beta3,gamma2 stably expressed in L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112238(5-(5-Cyclopropyl-[1,2,4]oxadiazol-3-yl)-3-(4-metho...)
Affinity DataKi:  240nMAssay Description:Displacement of [3H]Ro-151788 from human Gamma-aminobutyric acid A receptor alpha-2-beta-3-gamma-2 stably expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112238(5-(5-Cyclopropyl-[1,2,4]oxadiazol-3-yl)-3-(4-metho...)
Affinity DataKi:  310nMAssay Description:Inhibition of [3H]Ro-151788 binding to human GABA A receptor (alpha-1-beta-3-gamma-2) stably expressed in L(tk-) cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed