BDBM50113342 CHEMBL518383
SMILES Fc1ccc(NC(=O)c2n[nH]cc2NC(=O)c2c(F)cccc2F)cc1
InChI Key InChIKey=BDRDBXXWQDFXEC-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50113342
Affinity DataIC50: 30nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) by radiometric filter binding assayMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 3nMAssay Description:Inhibition of C-terminal His6-tagged human full length CDK2/N-terminal GST-tagged human full length Cyclin A using histone H1 and [gamma-32P]-ATP inc...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of full length GST-tagged human CDK1/cyclin BMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of full length GST-tagged human CDK2/Cyclin AMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of CDK1/cyclin B1 (unknown origin) using FAM-labeled peptide and ATP as substrate preincubated for 10 mins followed by substrate addition ...More data for this Ligand-Target Pair
TargetCyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
Key Laboratory Of Biomedical Materials Of Natural Macromolecules (Beijing University Of Chemical Technology)
Curated by ChEMBL
Key Laboratory Of Biomedical Materials Of Natural Macromolecules (Beijing University Of Chemical Technology)
Curated by ChEMBL
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of recombinant human full length CDK7/cyclin H1 expressed in Sf9 cells incubated for 10 mins by ADP-Glo reagent assayMore data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 1(Homo sapiens (Human))
Key Laboratory Of Biomedical Materials Of Natural Macromolecules (Beijing University Of Chemical Technology)
Curated by ChEMBL
Key Laboratory Of Biomedical Materials Of Natural Macromolecules (Beijing University Of Chemical Technology)
Curated by ChEMBL
Affinity DataIC50: 2.95E+4nMAssay Description:Inhibition of recombinant human full length CDK1/cyclin A2 expressed in Sf9 cells incubated for 10 mins by ADP-Glo reagent assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.52E+3nMAssay Description:Inhibition of recombinant human full length CDK2/cyclin A2 incubated for 10 mins by ADP-Glo reagent assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Key Laboratory Of Biomedical Materials Of Natural Macromolecules (Beijing University Of Chemical Technology)
Curated by ChEMBL
Key Laboratory Of Biomedical Materials Of Natural Macromolecules (Beijing University Of Chemical Technology)
Curated by ChEMBL
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of recombinant human full length CDK4/cyclin D1 expressed in Sf9 cells incubated for 10 mins by ADP-Glo reagent assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Key Laboratory Of Biomedical Materials Of Natural Macromolecules (Beijing University Of Chemical Technology)
Curated by ChEMBL
Key Laboratory Of Biomedical Materials Of Natural Macromolecules (Beijing University Of Chemical Technology)
Curated by ChEMBL
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of recombinant human full length CDK6/cyclin D3 incubated for 10 mins by ADP-Glo reagent assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of CDK2/cyclin A2 (unknown origin) using FAM-labeled peptide and ATP as substrate preincubated for 10 mins followed by substrate addition ...More data for this Ligand-Target Pair