BDBM50114693 4-[5-(4-Fluoro-phenyl)-2-(3-methanesulfinyl-benzylsulfanyl)-1H-imidazol-4-yl]-pyridine::4-[5-(4-Fluoro-phenyl)-2-(3-methanesulfinyl-benzylsulfanyl)-3H-imidazol-4-yl]-pyridine::CHEMBL143370

SMILES CS(=O)c1cccc(CSc2nc(c([nH]2)-c2ccc(F)cc2)-c2ccncc2)c1

InChI Key InChIKey=ASWWEASHSSNEMM-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50114693   

TargetMitogen-activated protein kinase 11/12/13/14(Human)
Eberhard-Karls-University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50114693(4-[5-(4-Fluoro-phenyl)-2-(3-methanesulfinyl-benzyl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of p38 MAP kinase related interleukin (IL1-beta (cytokine) release from human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Eberhard-Karls-University TüBingen

Curated by ChEMBL
LigandPNGBDBM50114693(4-[5-(4-Fluoro-phenyl)-2-(3-methanesulfinyl-benzyl...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of Mitogen-activated protein kinase p38 (P38 MAPK)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Eberhard-Karls-University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50114693(4-[5-(4-Fluoro-phenyl)-2-(3-methanesulfinyl-benzyl...)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of p38 MAP kinase related interleukin (IL1-beta (cytokine) release from human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Eberhard-Karls-University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50114693(4-[5-(4-Fluoro-phenyl)-2-(3-methanesulfinyl-benzyl...)
Affinity DataIC50: 2.35E+4nMAssay Description:Inhibition of p38 MAP kinase related TNF-alpha release from peripheral blood mononuclear cells (PBMC)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Eberhard-Karls-University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50114693(4-[5-(4-Fluoro-phenyl)-2-(3-methanesulfinyl-benzyl...)
Affinity DataIC50: 3.35E+4nMAssay Description:Inhibition of p38 MAP kinase related TNF-alpha release from human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed