BDBM50118221 9H-purine derivative::CHEMBL132722::DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER::alpha,beta-meATP

SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)CP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O

InChI Key InChIKey=CAWZRIXWFRFUQB-IOSLPCCCSA-N

Data  2 KI  1 IC50  9 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50118221   

LigandPNGBDBM50118221(9H-purine derivative | CHEMBL132722 | DIPHOSPHOMET...)
Affinity DataKi:  3.00E+5nMAssay Description:Inhibitory constant against rat kidney Methionine adenosyltransferase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50118221(9H-purine derivative | CHEMBL132722 | DIPHOSPHOMET...)
Affinity DataKi:  3.40E+5nMAssay Description:Inhibitory constant against rat Methionine adenosyltransferase was reportedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118221(9H-purine derivative | CHEMBL132722 | DIPHOSPHOMET...)
Affinity DataEC50: >1.00E+5nMAssay Description:Antagonist activity against phospholipase C coupled rat P2Y purinoceptor 12 (P2Y12)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 1(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118221(9H-purine derivative | CHEMBL132722 | DIPHOSPHOMET...)
Affinity DataEC50:  200nMAssay Description:The compound was evaluated for antagonist activity against recombinant human P2X purinoceptor 1 (P2X1 )More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 5(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118221(9H-purine derivative | CHEMBL132722 | DIPHOSPHOMET...)
Affinity DataEC50: >7.00E+3nMAssay Description:Antagonist activity against recombinant rat P2X purinoceptor 5 (P2X5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 2(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118221(9H-purine derivative | CHEMBL132722 | DIPHOSPHOMET...)
Affinity DataEC50:  1.00E+5nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat receptor P2X purinoceptor 2 (P2X2) at 10 uM, expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118221(9H-purine derivative | CHEMBL132722 | DIPHOSPHOMET...)
Affinity DataEC50:  740nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 10 uM, expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118221(9H-purine derivative | CHEMBL132722 | DIPHOSPHOMET...)
Affinity DataEC50:  3.30E+4nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 4 (P2X4) 3 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 1(Rat)
University of Urbino

Curated by ChEMBL
LigandPNGBDBM50118221(9H-purine derivative | CHEMBL132722 | DIPHOSPHOMET...)
Affinity DataIC50:  14nMAssay Description:Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118221(9H-purine derivative | CHEMBL132722 | DIPHOSPHOMET...)
Affinity DataEC50: >1.00E+5nMAssay Description:Antagonist activity against recombinant human P2X purinoceptor 7 (P2X7)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Wild turkey)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118221(9H-purine derivative | CHEMBL132722 | DIPHOSPHOMET...)
Affinity DataEC50: >1.00E+5nMAssay Description:Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of turkey erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 6(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118221(9H-purine derivative | CHEMBL132722 | DIPHOSPHOMET...)
Affinity DataEC50: >8.00E+3nMAssay Description:Antagonist activity against recombinant rat P2X purinoceptor 6 (P2X6 )More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed