BDBM501193 US11021511, Compound 1

SMILES CC1(O)C(OC2COP(O)(=O)OC3C(O)C(COP(O)(=O)OC12)OC3n1cnc2c1nc(N)[nH]c2=O)n1cnc2c(N)ncnc12

InChI Key InChIKey=HDXBKJZVSNDUJX-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 501193   

TargetStimulator of interferon genes protein [139-379,H232R](Human)
Janssen Biotech

US Patent
LigandPNGBDBM501193(US11021511, Compound 1)
Affinity DataEC50:  1.81E+3nMAssay Description:Agonism of the human STING pathway is assessed in THP1-ISG cells (Invivogen, cat #thp-isg) derived from human THP1 monocyte cell line by stable integ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetStimulator of interferon genes protein [139-379,H232R](Human)
Janssen Biotech

US Patent
LigandPNGBDBM501193(US11021511, Compound 1)
Affinity DataIC50: 5.45E+4nMAssay Description:The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′→5′)-monoph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent