BDBM50119585 CHEMBL3617746::US10413545, Compound 95::US9718813, Compound 95

SMILES Cn1cc(-c2ccc(-c3ccc(C4=NC(C)(C)C(=O)N4C[C@@H]4CCN(C(=O)C5(O)CC5)C4)c(F)c3)cc2)cn1

InChI Key InChIKey=PXRDSWCMKCLNIA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50119585   

TargetFatty acid synthase(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50119585BDBM50119585(CHEMBL3617746 | US9718813, Compound 95 | US1041354...)
Affinity DataIC50: 30nMAssay Description:Inhibition of fatty acid synthase (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50119585BDBM50119585(CHEMBL3617746 | US9718813, Compound 95 | US1041354...)
Affinity DataIC50: 30.2nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
US Patent

TargetFatty acid synthase(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50119585BDBM50119585(CHEMBL3617746 | US9718813, Compound 95 | US1041354...)
Affinity DataIC50: 30.2nMpH: 7.5 T: 2°CAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2018
Entry Details
US Patent