BDBM501208 US11021493, Example 127

SMILES CN1C(N)=N[C@](C)(c2cc(\C=C(/F)c3ccc(cn3)C#N)ccc2F)C2(CC2)S1(=O)=O

InChI Key InChIKey=BBNKDWRNDBPTOR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 501208   

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 501208BDBM501208(US11021493, Example 127)
Affinity DataIC50: 6nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetBeta-secretase 2(Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 501208BDBM501208(US11021493, Example 127)
Affinity DataIC50: 175nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetCathepsin D(Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 501208BDBM501208(US11021493, Example 127)
Affinity DataIC50: 1.29E+5nMAssay Description:Recombinant CatD was expressed in CHO cells. The assay buffer for CatD was 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent