BDBM50121323 CHEMBL3623079

SMILES COc1ccc(cc1S(=O)(=O)Nc1cccc(NCCNC(=O)c2ccccc2N(C)C)c1)-c1cccc(c1)C(=O)N(C)C

InChI Key InChIKey=BXJSAMKIFDDLGI-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50121323   

TargetOrexin receptor type 2(Human)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50121323(CHEMBL3623079)
Affinity DataEC50:  28nMAssay Description:Agonist activity at human OX2R expressed in CHOK1 cells by NFAT-response luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50121323(CHEMBL3623079)
Affinity DataEC50:  165nMAssay Description:Agonist activity at human OX2R stably expressed in CHO RD-HGA16 cells assessed as fluorescence changes measured after 30 mins by calcium mobilization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50121323(CHEMBL3623079)
Affinity DataEC50:  824nMAssay Description:Agonist activity at human OX1R stably expressed in CHO RD-HGA16 cells assessed as fluorescence changes measured after 30 mins by calcium mobilization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50121323(CHEMBL3623079)
Affinity DataEC50:  2.75E+3nMAssay Description:Agonist activity at human OX1R expressed in CHOK1 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed