BDBM50121334 2-ethoxy-13,22-dimethyl-(2S,13R)-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5(10),6,8,15,17,19(25)-heptaen-16-ol::Naltrindole analogue

SMILES CCO[C@]12Cc3c([nH]c4ccccc34)[C@]3(C)Oc4c5c(CC1N(C)CCC235)ccc4O

InChI Key

Data  4 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50121334   

TargetDelta-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50121334(2-ethoxy-13,22-dimethyl-(2S,13R)-14-oxa-11,22-diaz...)
Affinity DataKi:  8.80nMAssay Description:Compound was evaluated for the binding affinity towards Opioid receptor delta 1 in rat brain homogenates using [3H]DIDI as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article

TargetDelta-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50121334(2-ethoxy-13,22-dimethyl-(2S,13R)-14-oxa-11,22-diaz...)
Affinity DataKi:  8.81nMAssay Description:Compound was evaluated in 3 determinations for the agonistic activity in the Opioid receptor delta 1 of mouse vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article

TargetDelta-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50121334(2-ethoxy-13,22-dimethyl-(2S,13R)-14-oxa-11,22-diaz...)
Affinity DataEC50:  104nMAssay Description:Compound was evaluated in 3 determinations for the agonistic activity in the Opioid receptor delta 1 of mouse vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article

TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50121334(2-ethoxy-13,22-dimethyl-(2S,13R)-14-oxa-11,22-diaz...)
Affinity DataKi:  286nMAssay Description:Compound was evaluated for the binding affinity towards Opioid receptor kappa 1 in rat brain homogenates using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article

TargetMu-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50121334(2-ethoxy-13,22-dimethyl-(2S,13R)-14-oxa-11,22-diaz...)
Affinity DataKi:  715nMAssay Description:Compound was evaluated for the binding affinity towards mu opioid receptor in rat brain homogenates using [3H]DAMGO as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article