BDBM50122327 CHEMBL3622142

SMILES CCc1nc(Nc2nc3n(CC)c(cc3c3n(C)cnc23)C(=O)N(C2CC2)C2CC2)sc1C

InChI Key InChIKey=LNRVUHYHRIIHPZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50122327   

TargetTyrosine-protein kinase JAK2(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122327(CHEMBL3622142)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of recombinant JAK2 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122327(CHEMBL3622142)
Affinity DataIC50: 250nMAssay Description:Inhibition of recombinant JAK1 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122327(CHEMBL3622142)
Affinity DataIC50: 460nMAssay Description:Inhibition of recombinant JAK3 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed