BDBM50122583 CHEMBL324718::N-[4-(3-Bromo-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-acrylamide

SMILES COc1cc2ncc(C#N)c(Nc3cccc(Br)c3)c2cc1NC(=O)C=C

InChI Key InChIKey=HKLOKSUROGEMSK-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50122583   

TargetEpidermal growth factor receptor(Human)
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50122583(CHEMBL324718 | N-[4-(3-Bromo-phenylamino)-3-cyano-...)
Affinity DataIC50:  810nMAssay Description:Concentration required to inhibit autophosphorylation of cytoplasmic domain of epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50122583(CHEMBL324718 | N-[4-(3-Bromo-phenylamino)-3-cyano-...)
Affinity DataIC50:  4.68E+3nMAssay Description:Concentration required to inhibit autophosphorylation of cytoplasmic domain of human epidermal growth factor receptor-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEpidermal growth factor receptor(Human)
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50122583(CHEMBL324718 | N-[4-(3-Bromo-phenylamino)-3-cyano-...)
Affinity DataIC50:  8.10E+5nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article

TargetEpidermal growth factor receptor(Human)
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50122583(CHEMBL324718 | N-[4-(3-Bromo-phenylamino)-3-cyano-...)
Affinity DataIC50:  813nMAssay Description:Inhibition autophosphorylation of EGFR in human DiFi cells after 2 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEpidermal growth factor receptor(Human)
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50122583(CHEMBL324718 | N-[4-(3-Bromo-phenylamino)-3-cyano-...)
Affinity DataIC50:  810nMAssay Description:Inhibition of autophosphorylation of cytoplasmic domain of epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed