BDBM50123009 3-Methyl-5-(2-methyl-thiazol-4-ylethynyl)-pyridine::CHEMBL332396::US8609852, 80

SMILES Cc1nc(cs1)C#Cc1cncc(C)c1

InChI Key InChIKey=FNYSJYOTGKRVBK-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50123009   

TargetMetabotropic glutamate receptor 5(Rat)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50123009(3-Methyl-5-(2-methyl-thiazol-4-ylethynyl)-pyridine...)
Affinity DataKi:  3nM ΔG°:  -11.6kcal/moleT: 25°CAssay Description:Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetMetabotropic glutamate receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50123009(3-Methyl-5-(2-methyl-thiazol-4-ylethynyl)-pyridine...)
Affinity DataIC50:  3nMAssay Description:In vitro functional potency using an automated assay employing LtK-cells stably expressing human recombinant mGlu5 receptor by measuring changes in c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed