BDBM50123997 (3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-yl)-pyridin-3-yl-amine::CHEMBL422563

SMILES C[C@H]1C2Cc3ccc(Nc4cccnc4)cc3[C@@]1(C)CCN2CC1CC1

InChI Key InChIKey=OHSQUTOUXRPUSB-GDTQQENISA-N

Data  3 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50123997   

TargetKappa-type opioid receptor(Guinea pig)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50123997((3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hex...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity towards Opioid receptor kappa 1 from guinea pig brain using [3H]U69,593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Guinea pig)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50123997((3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hex...)
Affinity DataKi:  0.640nMAssay Description:Binding affinity towards Opioid receptor mu 1 from guinea pig brain using [3H]DAMGO as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50123997((3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hex...)
Affinity DataKi:  21nMAssay Description:Binding affinity towards Opioid receptor delta 1 from guinea pig brain using [3H]naltrindole as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50123997((3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hex...)
Affinity DataEC50:  10nMAssay Description:Incorporation of [35S]GTP-gamma-S, into CHO membranes expressing human Opioid receptor kappa 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed