BDBM50124528 CHEMBL170176::ethyl 4'-amino-1H,1'H-spiro[piperidine-4,2'-thieno[3,2-d]pyrimidine]-1-carboxylate::ethyl 4'-aminospiro[hexahydropyridine-4,2'-(1',2'-dihydrothieno[3,2-d]pyrimidine)]-1-carboxylate

SMILES CCOC(=O)N1CCC2(CC1)Nc1ccsc1C(N)=N2

InChI Key InChIKey=RLPGHWGMNJDXPL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50124528   

TargetNitric oxide synthase, inducible(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50124528(ethyl 4'-amino-1H,1'H-spiro[piperidine-4,2'-thieno...)
Affinity DataIC50: 300nMAssay Description:Inhibitory activity of compound against human inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50124528(ethyl 4'-amino-1H,1'H-spiro[piperidine-4,2'-thieno...)
Affinity DataIC50: 300nMAssay Description:Inhibition of iNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50124528(ethyl 4'-amino-1H,1'H-spiro[piperidine-4,2'-thieno...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50124528(ethyl 4'-amino-1H,1'H-spiro[piperidine-4,2'-thieno...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against human endothelial nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed