BDBM50126029 5-[1-Hydroxy-1-(3-methyl-3H-imidazol-4-yl)-3-phenyl-prop-2-ynyl]-2'-methyl-biphenyl-2-carbonitrile::CHEMBL24822

SMILES Cc1ccccc1-c1cc(ccc1C#N)C(O)(C#Cc1ccccc1)c1cncn1C

InChI Key InChIKey=TXMWWHNPHYEWNP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50126029   

LigandPNGBDBM50126029(5-[1-Hydroxy-1-(3-methyl-3H-imidazol-4-yl)-3-pheny...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of human FTase-catalyzed incorporation of [3H]FPP into recombinant Ras CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGeranylgeranyl transferase type-1 subunit beta(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50126029(5-[1-Hydroxy-1-(3-methyl-3H-imidazol-4-yl)-3-pheny...)
Affinity DataIC50: 240nMAssay Description:Inhibition of human GGTase-catalyzed incorporation of [3H]GGPP into biotinylated peptide of C-terminal of human K-RasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed