BDBM50127458 CHEMBL300394::N-Hydroxy-2-(7-methoxy-1,1-dioxo-1,3,4,5-tetrahydro-1lambda*6*-benzo[f][1,2,5]thiadiazepin-2-yl)-3-methyl-butyramide

SMILES COc1ccc2c(NCCN([C@H](C(C)C)C(=O)NO)S2(=O)=O)c1

InChI Key InChIKey=OQWWHTLOLOTDPO-CYBMUJFWSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50127458   

Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50127458(CHEMBL300394 | N-Hydroxy-2-(7-methoxy-1,1-dioxo-1,...)
Affinity DataKi:  52nMAssay Description:In vitro inhibitory activity against broad spectrum matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50127458(CHEMBL300394 | N-Hydroxy-2-(7-methoxy-1,1-dioxo-1,...)
Affinity DataKi:  71nMAssay Description:In vitro inhibitory activity against porcine tumor necrosis factor alpha converting enzyme (pTACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInterstitial collagenase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50127458(CHEMBL300394 | N-Hydroxy-2-(7-methoxy-1,1-dioxo-1,...)
Affinity DataKi:  732nMAssay Description:In vitro inhibitory activity against broad spectrum matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50127458(CHEMBL300394 | N-Hydroxy-2-(7-methoxy-1,1-dioxo-1,...)
Affinity DataKi:  751nMAssay Description:In vitro inhibitory activity against broad spectrum matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed