BDBM50128273 CHEMBL3628722

SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(-n3cc(CCF)nn3)c3ccccc3n2)cc1)-c1ccncc1

InChI Key InChIKey=WRLHTBBRLZXVDZ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50128273   

LigandPNGBDBM50128273(CHEMBL3628722)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of recombinant human PDE10A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50128273(CHEMBL3628722)
Affinity DataIC50: 1.57E+3nMAssay Description:Inhibition of recombinant human PDE4A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50128273(CHEMBL3628722)
Affinity DataIC50: 3.56E+3nMAssay Description:Inhibition of recombinant human PDE3B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50128273(CHEMBL3628722)
Affinity DataIC50: 4.51E+3nMAssay Description:Inhibition of recombinant human PDE3A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50128273(CHEMBL3628722)
Affinity DataIC50: 1.83E+4nMAssay Description:Inhibition of recombinant human PDE4B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed