BDBM50128692 5-{2-(3-Cyclopropoxy-4-difluoromethoxy-phenyl)-2-[6-(1-hydroxy-1-methyl-ethyl)-pyridin-3-yl]-ethyl}-3H-pyridin-2-one::CHEMBL81491

SMILES CC(C)(O)c1ccc(C(Cc2ccc(=O)[nH]c2)c2ccc(OC(F)F)c(OC3CC3)c2)cn1

InChI Key InChIKey=AFBUSBWYDGHNSP-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50128692   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50128692BDBM50128692(5-{2-(3-Cyclopropoxy-4-difluoromethoxy-phenyl)-2-[...)
Affinity DataIC50: 0.700nMAssay Description:In vitro inhibitory activity was determined against human Phosphodiesterase 4 isoform using a construct representing the common region of spliced var...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50128692BDBM50128692(5-{2-(3-Cyclopropoxy-4-difluoromethoxy-phenyl)-2-[...)
Affinity DataKi:  5.59E+4nMAssay Description:In vitro displacement of [35S]-MK- 499 from HEK 293 cells stably transfected with hERG voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed