BDBM50129055 (S)-2-Acetylamino-N-hydroxy-2-{(R)-1-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-3-yl}-acetamide::CHEMBL62964

SMILES CC(=O)N[C@@H]([C@H]1CCN(C1=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO

InChI Key InChIKey=CHRGPXOYOHYPAP-GGAORHGYSA-N

Data  3 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50129055   

Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129055((S)-2-Acetylamino-N-hydroxy-2-{(R)-1-[4-(2-methyl-...)
Affinity DataKi:  194nMAssay Description:In vitro inhibition of Matrix metalloproteinase-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129055((S)-2-Acetylamino-N-hydroxy-2-{(R)-1-[4-(2-methyl-...)
Affinity DataKi: >2.00E+3nMAssay Description:In vitro inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInterstitial collagenase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129055((S)-2-Acetylamino-N-hydroxy-2-{(R)-1-[4-(2-methyl-...)
Affinity DataKi: >5.00E+3nMAssay Description:In vitro inhibition of Matrix metalloproteinase-1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129055((S)-2-Acetylamino-N-hydroxy-2-{(R)-1-[4-(2-methyl-...)
Affinity DataIC50:  1.56E+3nMAssay Description:Inhibition of TNF-alpha production from LPS stimulated human whole blood.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDisintegrin and metalloproteinase domain-containing protein 17(Pig)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129055((S)-2-Acetylamino-N-hydroxy-2-{(R)-1-[4-(2-methyl-...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of TNF-alpha converting enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed