BDBM50130610 (E)-N-[(S)-1-(3-Morpholin-4-yl-phenyl)-ethyl]-3-phenyl-acrylamide::(E)-N-[1-((S)-3-Morpholin-4-yl-phenyl)-ethyl]-3-phenyl-acrylamide::CHEMBL317935::N-[1-(3-Morpholin-4-yl-phenyl)-ethyl]-3-phenyl-acrylamide
SMILES C[C@H](NC(=O)\C=C\c1ccccc1)c1cccc(c1)N1CCOCC1
InChI Key InChIKey=QMIMHUDEVKGOTQ-DVQDXYAYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 17 hits for monomerid = 50130610
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataEC50: 690nMAssay Description:Effect on resting membrane potential in SH-SY5Y human neuroblastoma cells expressing native KCNQ channelsMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2(Mouse)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataEC50: 3.20E+3nMAssay Description:Effect on outward potassium currents in whole-cell patchclamp assay of HEK 293 cells expressing cloned mouse KCNQ2 channel at -40 mVMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2(Mouse)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataEC50: 3.28E+3nMAssay Description:Whole-cell patch-clamp on recombinant mouse KCNQ2 channels expressed in HEK 293 cells at -40 mVMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataEC50: 3.00E+3nMAssay Description:Effective concentration against Potassium voltage gated channel KQT-like subfamily, member 2 expressed in HEK 293 cellsMore data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of recombinant human Cytochrome P450 2C9More data for this Ligand-Target Pair
TargetCytochrome P450 1A2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 7.80E+4nMAssay Description:Inhibition of recombinant human Cytochrome P450 1A2More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 9.60E+4nMAssay Description:Inhibition of recombinant human Cytochrome P450 3A4 with BFC [7-benzyloxy-4-trifluoromethylcoumarin] after 5 minutesMore data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of recombinant human Cytochrome P450 3A4 using BFC [7-benzyloxy-4-trifluoromethylcoumarin] after 30 minutesMore data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of recombinant human Cytochrome P450 3A4 with BFC [7-benzyloxy-4-trifluoromethylcoumarin]More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of recombinant human Cytochrome P450 19A1More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of recombinant human Cytochrome P450 3A4 with BFC [7-benzyloxy-4-trifluoromethylcoumarin] after 45 minutesMore data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 6.20E+4nMAssay Description:Inhibition of recombinant human Cytochrome P450 3A4 with BFC [7-benzyloxy-4-trifluoromethylcoumarin] after 15 minutesMore data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human Cytochrome P450 2D6More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataEC50: 690nMAssay Description:Effective concentration against Potassium voltage gated channel, KQT-like subfamily, member 2 expressed in SH-SY5Y human neuroblastoma cellsMore data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 7.60E+4nMAssay Description:Inhibition of recombinant human Cytochrome P450 3A4 with BenzoylresorufinMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2(Mouse)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataEC50: 3.20E+3nMAssay Description:Induction of mouse KCNQ2 expressed in HEK293 cells at -40 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2(Mouse)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataEC50: 6.00E+3nMAssay Description:Induced current in Xenopus laevis oocytes expressing cloned mKCNQ2 channelsMore data for this Ligand-Target Pair