BDBM50131266 CHEMBL3634758::US9260425, 173

SMILES Cn1cc(cn1)-c1cc2c(n[nH]c2cn1)-c1cccc(n1)N1CCC[C@H](N)C1

InChI Key InChIKey=UZSKGLPUMSUOBY-UHFFFAOYSA-N

Data  7 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50131266   

TargetSerine/threonine-protein kinase pim-3(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50131266(CHEMBL3634758 | US9260425, 173)
Affinity DataKi:  0.0150nMAssay Description:Inhibition of Pim3 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-3(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50131266(CHEMBL3634758 | US9260425, 173)
Affinity DataKi:  0.0200nMAssay Description:Inhibition of PIM3 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 mins in presence of ATP by caliper microfluidic mobility shift as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Genetech

US Patent
LigandPNGBDBM50131266(CHEMBL3634758 | US9260425, 173)
Affinity DataKi:  0.0600nMpH: 7.2Assay Description:PIM-1, PIM-2, and PIM-3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Genetech

US Patent
LigandPNGBDBM50131266(CHEMBL3634758 | US9260425, 173)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of Pim1 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Genetech

US Patent
LigandPNGBDBM50131266(CHEMBL3634758 | US9260425, 173)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of PIM1 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 mins in presence of ATP by caliper microfluidic mobility shift as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50131266(CHEMBL3634758 | US9260425, 173)
Affinity DataKi:  0.200nMAssay Description:Inhibition of PIM2 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 mins in presence of ATP by caliper microfluidic mobility shift as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50131266(CHEMBL3634758 | US9260425, 173)
Affinity DataKi:  0.260nMAssay Description:Inhibition of Pim2 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2016
Entry Details Article
PubMed